Pathological Classification Schemes of Hodgkin's Lymphoma
Scheme | Year | Subtypes |
Jackson and Parkers Classification | 1944 | Granuloma |
Paragranuloma | ||
Sarcoma | ||
Luke and Butler Classification | 1964 | Lymphocytic and/or histiocytic, nodular |
Lymphocytic and/or histiocytic, diffuse | ||
Nodular sclerosis | ||
Mixed Cellularity | ||
Diffuse Fibrosis | ||
Reticular | ||
Rye's Classification | 1965 | Lymphocyte predominance |
Nodular sclerosis | ||
Mixed Cellularity | ||
Lymphocyte Depletion | ||
Revised European–American lymphoma (REAL) classification | 1994 | Nodular lymphocyte predominance nodular/diffuse |
Classical Nodular Sclerosis | ||
Classical Mixed Cellularity | ||
Classical Lymphocyte Depletion | ||
Classical Lymphocyte Rich Diffuse (Provisional) | ||
WHO scheme | 1997 | Nodular Lymphocyte Predominant HL |
Classical Nodular sclerosis HL (grades 1 and 2) | ||
Classical Lymphocyte rich classic HL* | ||
Classical Mixed cellularity HL | ||
Classical Lymphocyte depleted HL | ||
Unclassifiable classic HL |
*This includes a nodular (common) and a diffuse (rare) form in contrast to the REAL classification.
!!Note the difference between predominant and rich!!
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